Insulin-mediated sympathoexcitation in obesity and type 2 diabetes.

نویسنده

  • M S Muntzel
چکیده

9. Babbs C, Warnes TW, Torrance HB, Ballardie FW. IgA nephro17. Lomax-Smith JD, Zabrowarny LA, Howarth GS, Seymour pathy in non-cirrhotic portal hypertension. Gut 1990; 32: AAE, Woodroffe AJ. The immunochemical characterisation of 225–226 mesangial IgA deposits. Am J Pathol 1983; 113: 359–364 10. Berger J, Yaneva H, Nabarra B. Glomerular changes in patients 18. Giron JA, Alvarez-Mon M, Menéndez-Caro J et al. Increased with cirrhosis of the liver. Adv Nephrol 1977; 7: 3–14 spontaneous and lymphokine-conditioned IgA and IgG synthesis 11. Kutteh WH, Prince SJ Phillips JO, Spenney JG, by B-cells from alcoholic cirrhotic patients. Hepatology 1992; Mestecky J. Properties of IgA in serum of individuals with liver 16: 664–670 disease and in hepatic bile. Gastroenterology 1982; 82: 184–93 19. Deviere J, Content J, Deny C et al. IgA and Interleukin 6 form 12. Sancho J, Egido J, Sanchez-Crespo M, Blasco R. Detection of a positive secretory feedback loop: study of normal subjects and monomeric and polymeric IgA containing immune complexes alcoholic cirrhotics. Gastroenterology 1992; 103: 1296–1301 in serum and kidney of patients with alcoholic liver disease. Clin 20. Feehally J, Allen AC, Pathogenesis of IgA nephropathy. Ann Exp Immunol 1981; 47: 327–335 Med Interne 1999; 150: 16–23 13. Coppo R, Aricò S, Piccoli G et al. Presence and origin of IgA121. Hiki Y, Kokubo T, Iwase H et al. Underglycosylation of IgA1 and IgA2-containing circulating immune complexes in chronic hinge plays a certain role for its glomerular deposition in IgA alcoholic liver disease with and without glomerulonephritis. Clin nephropathy. J Am Soc Nephrol 1999; 10: 760–769 Immunol Immunopathol 1985; 35: 1–8 22. Roccatello D, Picciotto G, Torchio M et al. Removal systems 14. Delacroix DL, Elken KB, Genbel AP, Hodgson HJF, Dive C, of IgA and IgA-containing complexes in IGAN and cirrhosis Vaerman JP. Changes in size, subclass, and metabolic properties patients. Lab Invest 1993; 69(6): 714–723 of serum immunoglobulin A in liver diseases and other diseases 23. Burgess J, Baenziger J, Brown W. Abnormal surface distribution with high serum immunoglobulin A. J Clin Invest 1983; 71: of the human asialoglycoprotein receptor in cirrhosis. 358–367 Hepatology 1992; 15: 702–706 15. Van de Wiel A, Delacroix DL, Van Hattum J, Schuurman H-J, 24. Silvain C, Patry C, Launay P, Lehuen A, Monteiro RC. Altered Kater L. Characteristics of serum IgA and liver IgA deposits in expression of monocyte immunoglobulin A Fc Receptor is alcoholic liver disease. Hepatology 1987; 7(1): 95–99 associated with defective endocytosis in patients with alcoholic 16. André C, Berthoux FC, André F, Gillon J, Genin C, Sabatier cirrhosis: Potential role for IFN-c. J Immunol 1995; 155: J-C. Prevalence of IgA2 deposits on IgA nephropathies. A clue to their pathogenesis. N Engl J Med 1980; 303(23): 1343–1346 1606–1618

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

New Insight into the Relation between Adiponectin and Diabetes

Diabetes mellitus is a group of metabolic diseases. Insulin resistance is defined as a state that needs more insulin to get the biological effects achieved by a lower amount of insulin in the normal state. Several molecules which are secreted through adipocytes have been involved in insulin resistance and type 2 diabetes mellitus. Adiponectin as a 244 amino acid protein is exclusively expressed...

متن کامل

The Role of Fetuin-A in Diabetes and Obesity: The Mechanism and Action

Fetuin-A is a phosphorylated glycoprotein produced by liver.It by binding to calcium ion inhibits ectopic calcium deposition and protects vascular calcification. Fetuin-A acts as a multifactorial protein and its role has been documented from brain development to bone remodeling and immune function, regulation of insulin activity, hepatocyte growth factor activity and inhibition lymphocyte blast...

متن کامل

Insulin and Sympathoexcitation: It Is Not All in Your Head

Obesity and weight gain are frequently associated with increases in blood pressure, driven in part by sympathoexcitation (1). Obesity also is linked with insulin resistance and is associated with ongoing public health concerns, including the socalled metabolic syndrome (2). Even small increases in plasma insulin concentration (as low as one-fifth of that achieved after a mixed meal) (3) have ma...

متن کامل

ارتباط سطح سرمی رزیستین با شاخص های مقاومت به انسولین در افراد چاق دیابتی و غیر دیابتی

Background: Resistin, an adipocyte secreted factor, has been suggested to link obesity with type 2 diabetes and insulin resistance in rodent models but its relevance to human diabetes remains uncertain. The aim of this study was to investigate the relationship between serum resistin concentrations with insulin resistance and obesity indices in type 2 diabetes and non-diabetic obese subjects.Met...

متن کامل

INVESTIGATION OF METHYLATION OF TNF-Α GENE PROMOTER IN PATIENTS WITH TYPE 2 DIABETES

Background: Type II diabetes is a chronic inflammatory condition that is associated with a combination of genetic and environmental factors. Tumor necrosis factor alpha or TNF-α as an adipocyte cytokine, which affects the signaling pathway of insulin, can contribute to insulin resistance in type 2 diabetes patients. Considering the importance of epigenetic changes in multifactorial diseases, th...

متن کامل

Optimization of Agrobacterium-mediated transformation in oyster mushroom (Pleurotus ostreatus) by vector containing human pro-insulin gene

Transferring foreign genes into mushroom mediated by Agrobacterium tumefaciens is a standard technique in genetic engineering. Recombinant human insulin has been greatly used in the treatment of type I diabetes. The production of edible mushroom derived insulin should facilitate oral delivery. In this study we used the Agrobacterium tumefaciens mediated transformation method for the transfer an...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

دوره 14 10  شماره 

صفحات  -

تاریخ انتشار 1999